While globalization commonly refers to the increasing interdependence between nations and regions in the spheres of finance, trade, information technology, and human mobility in recent decades, revisionist accounts of world history suggest that global connections had long existed since as early as 207 BCE. Yet, even newer accounts of globalization pay insufficient attentions to how gender, sex, sexuality, and desire are central to global processes. Taking gender and sexuality seriously in our understanding of globalization raises new questions and opens up exciting research directions. For instance, more people from North America are turning to Thailand as a potential site for sex reassignment surgery; the #MeToo movement has created different impacts globally as it builds on existing feminist movements in India, China, Hong Kong, Taiwan, South Korea, and elsewhere. The NGOization of feminism sometimes results in more stringent control over prostitution and the rights of sex workers locally. The rise of populism and political conservatism globally may erode existing programs in birth control and women’s rights. LGBT adoption increasingly takes place on a transnational scale. Globalization turns out to be intimately tied to the political economies of gender, sex, and sexualities. The Global Sexualities Initiative under the CSGC at HKU serves as a hub for research on the transnational and global dimensions of sexualities in Hong Kong and beyond. Through public lectures, academic publication, and other knowledge exchange platforms, the global sexualities initiative aims to enrich our understanding of gender, sexuality, feminism, transgender identity, and queer issues in local, regional, and global configurations.